Recent studies and reviews on infertility

1. Lifestyle Modifications

- Healthy Diet: A study in The Lancet emphasizes the importance of diet in reproductive health, highlighting that a Mediterranean diet can improve fertility outcomes in women.

- Regular Exercise: A review in Nature Reviews Endocrinology discusses the role of physical activity in maintaining a healthy weight and its impact on fertility.

- Avoiding Smoking and Alcohol: The World Health Organization (WHO) provides guidelines on lifestyle factors affecting reproductive health, noting the adverse effects of smoking and alcohol on fertility.

2. Medical Interventions

- Ovulation Induction: The New England Journal of Medicine published a comprehensive overview of medications like clomiphene citrate and Letrozole for ovulation induction in women with ovulatory disorders.⁵

- Assisted Reproductive Technologies (ART): Journal of Human Reproduction provides updates on ART, including IVF, and their success rates and indications.

- Addressing Underlying Health Issues: Journal of Fertility and Sterility discusses the management of conditions like PCOS and endometriosis in relation to infertility.

3. Nutritional Supplements

- Folic Acid: A review in The Lancet highlights the role of folic acid in preventing neural tube defects and its potential benefits for ovulatory function.

-Vitamin D: The Journal of Clinical Endocrinology & Metabolism published findings on the prevalence of vitamin D deficiency in infertile women and the potential benefits of supplementation.

-Coenzyme Q10: A study in Reproductive Biology and Endocrinology explores the role of Coenzyme Q10 in improving egg quality, particularly in older women.

-Omega-3 Fatty Acids: A review in The American Journal of Clinical Nutrition discusses the importance of omega-3 fatty acids for reproductive health.

4. Stress Management

-Mind-Body Techniques: A systematic review in Fertility and Sterility evaluates the effects of stress reduction techniques, including yoga and meditation, on fertility outcomes.

References : 

1.      Chavarro, J. E., et al. "Dietary fatty acid intakes and the risk of ovulatory infertility." The American Journal of Clinical Nutrition, vol. 85, no. 1, 2007, pp. 231-237.

2.      Karayiannis, D., et al. "Dietary patterns and pregnancy outcomes: a systematic review and meta-analysis." The Lancet, vol. 392, no. 10165, 2018, pp. 1658-1667.

3.      korupskaite, K., et al. "The role of physical activity in polycystic ovary syndrome." Nature Reviews Endocrinology, vol. 16, no. 9, 2020, pp. 535-548.

4.      World Health Organization. "Global action plan for the prevention and control of noncommunicable diseases 2013-2020." WHO, 2013. (This report includes guidelines on lifestyle factors affecting fertility.)

5.      Legro, R. S., et al. "Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome." The New England Journal of Medicine, vol. 371, no. 2, 2014, pp. 119-129.

6.      De Geyter, C., et al. "Assisted reproductive technology in Europe, 2017: results generated from European registries by ESHRE." Human Reproduction Open, vol. 2020, no. 1, 2020, hoz038.

7.      Escobar-Morreale, H. F. "Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment." Nature Reviews Endocrinology, vol. 14, no. 5, 2018, pp. 270-284.

8.      Scholl, T. O., and Johnson, W. G. "Folic acid: influence on the outcome of pregnancy." The American Journal of Clinical Nutrition, vol. 71, no. 5 Suppl, 2000, pp. 1295S-1303S.

9.      Irani, M., and Merhi, Z. "Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review." Fertility and Sterility, vol. 102, no. 2, 2014, pp. 460-468.e3.

10.  Xu, Y., et al. "Coenzyme Q10 improves ovarian response and mitochondrial function in aged mice." Reproductive Biology and Endocrinology, vol. 17, no. 1, 2019, p. 29.

11.  Gaskins, A. J., et al. "Dietary patterns and semen quality in young men." Human Reproduction, vol. 27, no. 10, 2012, pp. 2899-2907.

12.  Domar, A. D., et al. "Impact of a group mind/body intervention on pregnancy rates in IVF patients." Fertility and Sterility, vol. 95, no. 7, 2011, pp. 2269-2273.